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Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. There are no data with Augmentin and allopurinol administered concurrently.

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